On the other hand, because of the α-RIT and the inflammatory and/or immunological (e.g. Figure B in S1 File and the slight increase of H2Kb/OVA257–264 complex expression we observed on 5T33-OVA cells after irradiation) context induced around the tumor, the activated OT-I CD8+ T cells might exert their anti-tumor activity in a larger extent and more efficiently than after ACT alone. The gene discussed is CD8A; the disease is neoplasm.