RHOC and invasive carcinoma: Islam et al. [7] in 2013 demonstrated in vitro (using UM-SCC-1 squamous cell carcinoma cells derived from floor of the mouth and UM-SCC-47 squamous cell carcinoma cells derived from floor of the tongue) and also in vivo that atorvastatin treatment reduces the activity of RhoC (a GTPase belonging to Ras superfamily, which is over-expressed in a wide range of invasive carcinomas) to 48% of control in UM-SCC-1 cells and to 52% in UM SCC-47 cells.