After additional adjustment for other risk factors, including BMI, hypertension duration, current smoking and drinking status, diabetes, LDL, HDL, plasma glucose, mean arterial pressure, heart rate, neutrophil account, urine albumin creatinine ratio, serum creatinine, anti-hypertensive treatment and statin use, the strength of association attenuated but was still significant. The gene discussed is ALB; the disease is diabetes mellitus.