PLA2G7 and familial isolated congenital asplenia: In models only adjusted with sex and age, the Lp-PLA2 mass was significantly associated with isolated ICAS (OR: 2.3; 95% CI: 1.14–4.64), and concurrent extraintracranial stenosis (OR: 3.93; 95% CI: 1.62–9.51) (Table 2).