HIF-1α enhances the hepatic inflammation, fibrosis and cancer by inducing its target genes such as vascular endothelial growth factor, plasminogen activator inhibitor-1, prolyl 4-hydroxylase, alpha peptide 1 (P4HA1), lysyl oxidase (LOX) and endoplasmic reticulum oxidoreductin 1-like (ERO1L) [24–26]. Here, ERO1A is linked to cancer.