F2 and blood coagulation disease: Therapy with purified or recombinant coagulation factors, such as fibrinogen, prothrombin complex concentrates (PCCs) and recombinant activated coagulation factor VII (rFVIIa, NovoSeven, Novo Nordisk, Denmark), has been shown to reduce severe bleeding and may thus be used as an approach to restore coagulation in traumatic injury complicated by coagulopathy [4–6].