Consistent with these more qualitative histological observations, separate quantitative comparisons of multiple inflammatory cytokines known to influence colitis severity (IL-1β, TNFα, IL-6, IL-10, IL-17) in colonic homogenates from FXIII−/− and WT mice following 7 days of DSS exposure were similar between genotypes (Fig 2G). This evidence concerns the gene TNF and colitis.