NTRK1 and neoplasm: FGF/FGFR signalling contributes to tumour generation and progression through activating FGFR genomic alterations (driver point-mutations, fusions and amplifications) (Greulich and Pollock, 2011, Wesche et al., 2011, Sabnis and Bivona, 2013), as a positive regulator of tumour neoangiogenesis (Turner and Grose, 2010) and as a mediator of resistance to endocrine (Turner et al., 2010) and targeted therapies to related oncogenic pathways, in particular to signalling by other receptor tyrosine kinases such as epidermal growth factor receptor (EGFR) (Wilson et al., 2012, Crystal et al., 2014).