In contrast, the FGFR1-equivalent substitution in FGFR3 (V555M) is highly likely to occur and was previously identified in the context of a cancer cell line (multiple myeloma KMS-11) dependent on an FGFR3 Y373C driver mutation (Chell et al., 2013). The gene discussed is FGFR1; the disease is AL amyloidosis.