Given the well documented association between BRAF mutant CRC and the CpG island methylator phenotype (CIMP) [6, 7], we examined the colorectal cancer TCGA to identify genes that were highly differentially methylated between BRAF mutant and wild type cases to identify candidates worthy of further analysis to unravel the clinical finding of poor outcomes after adjuvant FU/LV. This evidence concerns the gene BRAF and colorectal cancer.