On examination of CpG island II in the intronic region, because of the uniformity of methylation observed, we took the average methylation across all 11 CpG's and used it in a Cox regression model, correcting for age, gender, chemotherapy status, MSI status, CIN status and BRAF/KRAS mutation status. This evidence concerns the gene BRAF and cervical squamous intraepithelial neoplasia.