The AP2 transcription factor family consist of five subtypes, AP2- α,β,χ,δ and AP2-ε, and are located predominantly in the nucleus where they regulate transcription and interact with other signal transduction pathways., AP2-a has been shown to modulate the Wnt signalling pathway 7 by interacting with the Adenomatous Polyposis Coli (APC) protein, the key protein in colorectal cancer development. Here, APC is linked to colorectal cancer.