S100A2 and prostate intraepithelial neoplasia: One the other hand, contrary to the results on differential S100A2 expression in different grades of prostate adenocarcinoma, no difference in methylation status of S100A2 was found between high-grade prostate intraepithelial neoplasia and benign prostate hyperplasia, in all of which observed methylation levels were consistently high [12].