A recent work suggests that in clear RCC a cumulative number of altered biomarkers in mTOR pathway (p-AKT, p-P706SK, p-mTOR, HIF-1alfa, Raptor, PTEN, P13K, p-4EBP-1) correlates with aggressive tumour biology (tumour stage and grade) and inferior disease outcome [33]. The gene discussed is PTEN; the disease is renal cell carcinoma.