Overall, p-mTOR expression significantly correlates with p-AKT (concordance r=0.29, P=0.05), p-P70S6K (r=0.35, P=0.001), and p-4E-BP1 (r=0.41, P=0.0001) positive staining consistent with the hypothesis that the mTOR pathway is activated in a subset of MM patients. The gene discussed is EIF4EBP1; the disease is Miyoshi myopathy.