As such, the human DDX58 gene product is a viral sensor for infection [57], the human P8 gene is a putative tumor suppressor that controls metastatic behavior [58], the human LGALS3 gene is a marker of tumor progression [59], the human BST2 gene is overexpressed in breast cancer and is involved in tumor metastasis [60], and finally, the human CEACAM-1 gene is involved in angiogenesis in non-small cell lung cancer [61]. Here, RIGI is linked to breast cancer.