When introducing APOBEC3A and APOBEC3B into yeast, genome-wide mutation patterns of APOBEC3A- and APOBEC3B-mediated deamination show strong similarity to mutation signatures found in breast cancer, which strengthens the proposed role of APOBEC3B, and maybe also APOBEC3A, in breast cancer hypermutation [35]. This evidence concerns the gene APOBEC3B and breast cancer.