CCR5 and malaria: AIDS is a lethal infectious disease of the immune system caused by the human immunodeficiency virus (HIV), which can be viewed as a paradigm for P. vivax-induced-malaria since like its protozoal counterpart, it requires an interaction between an HIV protein, the viral glycoprotein gp120, and either one of the human chemokine receptors CCR5 or CXCR4.