Nicol and coworkers used an immunoaffinity approach to quantify carincoembryonic antigen (CEA), secretory leukocyte peptidase inhibitor, tissue factor pathway inhibitor 1,2 (TFPI/TFPI2), and metalloproteinase inhibitor 1 (TIMP1) in sera samples from lung cancer patients down to low ng/ml levels 106. The gene discussed is TIMP1; the disease is lung carcinoma.