Mutations in the GBA1 gene are numerically the most important genetic risk factor for developing Parkinson's disease (PD).1, 2 A large multicenter study showed that PD patients had an odds ratio of over 5 for carrying a GBA1 mutation, compared with a similar‐sized control population.1GBA1 encodes for the lysosomal enzyme glucocerebrosidase (GCase), which catabolizes the sphingolipid glucosylceramide (GlcCer) to glucose and ceramide. This evidence concerns the gene GBA1 and Parkinson disease.