WNT1 and Cachexia: The results demonstrated that the body weight between wild-type mice and Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice was similar at P0 and P7; however, it was significantly different at P14 and P21 (P<0.05), indicating that the observed changes of the TMJ in Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice may have affected the function of the TMJ, leading to a reduction in body weight and the development of a wasting syndrome.