For example, increased expression levels of vascular endothelial growth factor A (VEGFA) have been reported to induce metastasis and OS development (5–7), the major angiogenic factors, VEGF165 and VEGF189, may be critical for neovascularisation in OS (8), and pigment epithelium-derived factor (PEDF) not only induces apoptotic cell death in OS cells, but also suppress the expression of VEGF, resulting in the inhibition of tumor angiogenesis (9). This evidence concerns the gene VEGFA and neoplasm.