SCN5A and malignant colon neoplasm: Our previous work has demonstrated that NaV1.5 VGSC isoform (encoded by SCN5A) is responsible for invasivity of colon cancer cells as ‘knockdown’ of this isoform with either tetrodotoxin (TTX), a specific inhibitor of VGSCs, or siRNA-mediated targeting led to a significant loss of baseline invasion4.