Mild and focal mesangio-proliferative glomerulonephritis was observed in the majority of pristane-inoculated C57/BJ mice (Fig. 3) by light microscopy (CX41-12C02; Olympus); however, none of the B7-1 antibody or B7-1 shRNA mice had diffuse proliferative or chronic lesions. Here, CD80 is linked to glomerulonephritis.