GAB2 and chronic myelogenous leukemia, BCR-ABL1 positive: The first evidence for the critical contribution of Gab2 to leukemogenesis was an investigation, which demonstrated that myeloid progenitors from Gab2-deficient mice are resistant to transformation by the BCR-ABL oncoprotein, which arises from a chromosomal translocation found in >90% of patients with chronic myeloid leukaemia (CML).