ASXL1 has been reported to interact directly with EZH2 and EED, catalytic and scaffold subunits, respectively, of the PRC2 methyltransferase complex that deposits H3K27me3; moreover, short hairpin RNA-mediated depletion of ASXL1 in a human leukemia cell line resulted in a decrease in bulk H3K27me3 levels and loss of the H3K27me3 mark at multiple genomic loci26. The gene discussed is ASXL1; the disease is leukemia.