Of particular interest UTRN which mediates several mitochondria dependent apoptosis pathways, was found to be significantly upregulated in Ewing cell lines (average 22.7% increase) which undergo apoptosis following XI-006 treatment, and repressed in osteosarcoma cell lines (average 31.9% decrease) (P = 0.025) which undergo cell-cycle arrest following XI-006 treatment. This evidence concerns the gene UTRN and osteosarcoma.