Across all Ewing and osteosarcoma cell lines eleven genes were found to be either significantly (P < 0.05, Bonferroni correction) repressed (KIF20A, IDH1, SCD, GPSM2, EIF2AK4, HIBCH) or induced (STK19, DNAJC24, MTG2, FAM175B, CYB5D1) following non DNA-damaging XI-006 treatment (0.5 μM) (Table 3). Here, CYB5D1 is linked to osteosarcoma.