In contrast, a small randomized control trial of Danish type 2 diabetes patients showed a borderline increase in C-peptide production with vitamin D supplementation (11,200 IU/d for 2 weeks followed by 5,600 IU/d for 10 weeks) versus placebo for 12 weeks without a change in other measures of insulin sensitivity such as HOMA-IR28. The gene discussed is INS; the disease is type 2 diabetes mellitus.