Studies of different cancer types have shown that CAFs are located in the vicinity of tumor cells and are able to enhance tumor growth through the secretion of growth factors (e.g., transforming growth factor-μ), matrix degrading enzymes [e.g., matrix metalloproteinases (MMPs)], and angiogenic factors (e.g., vascular endothelial growth factor) [25–30]. This evidence concerns the gene VEGFA and neoplasm.