Yoon et al. [11], using a human chondrosarcoma cell line (HTB-94) showed that α-MSH inhibited TNF-α-induced expression of MMP-13, through a decrease in mitogen-activated protein kinase (MAPK) p38 phosphorylation and subsequent activation of nuclear factor-κB (NF-κB). This evidence concerns the gene MMP13 and chondrosarcoma.