Notably, cancer tissues had significantly lower TET2 levels (median: 0.045; mean: 0.053; SD: 0.03) than did normal mucosa (median: 0.087; mean: 0.090; SD 0.03; P < 0.0001, paired t-test; Fig. 2B); and significantly higher TET3 levels (median: 0.030; mean: 0.037; SD: 0.032) than did normal mucosa (median 0.024; mean 0.026; SD 0.01; P = 0.0023; Fig. 2C). This evidence concerns the gene TET2 and cancer.