TP53 and renal carcinoma: As it has demonstrated that loss of ASC/TMS1 correlates with reduced UVB-induced p53 activation in murine skin previously, so we explored whether loss of ASC/TMS1 might reduce p53 activation in renal cancer Caki-2 cells following treatment with DNA damaging agents etoposide and doxorubicin, two known inducer of p53 activation.