ANG and cyst: ACE angiotensin-converting enzyme, ACE2 angiotensin-converting enzyme 2, AGT angiotensinogen, AngII angiotensin II, Ang-(1-7) angiotensin (1-7), C cyst-lining epithelial cells, DT distal tubules, ADPKD-CKD polycystic kidney disease – chronic kidney disease stage, ADPKD-ESRD polycystic kidney disease – end-stage renal disease stage, PT Proximal tubule