Notably, the expression level of AGT was much stronger in case I (PKD-CKD, eGFR 69 mL/min/1.73 m2 with hypertension) than that in case II (PKD-ESRD, eGFR 11 mL/min/1.73 m2 with hypertension, pre-dialysis) suggesting that urinary AGT/Cr may be more useful in the early stage of renal disease. This evidence concerns the gene AGT and chronic kidney disease.