SHANK3 and schizophrenia: For example, Gauthier and colleagues showed that a rare variant of SH3 and multiple ankyrin repeat domains 3 (SHANK3) associated with schizophrenia could not rescue head size and swimming deficits in a zebrafish shank3 LOF embryo, whereas a second variant and wild-type RNA could (Gauthier et al., 2010), suggesting that the first variant was pathological.