MECP2 and Down syndrome: Mouse models have been developed for candidate schizophrenia risk loci, such as disrupted in schizophrenia 1 (DISC1) and 22q11.2 deletion syndrome, and for candidate autism risk loci, such as methyl CpG-binding protein 2 (MECP2) and 15q11-13 deletion/duplication syndromes (Amir et al., 1999; Bundey et al., 1994; Sandanam et al., 1997).