MSH2 and cancer: CRAVAT analysis (Table 3) was performed in two ways: firstly by querying a functional effect and then by proceeding with cancer driver analyses: a general analysis and subsequently a targeted one, choosing “colon” as the tissue type of interest, on the basis of the findings depicted in Table 1 regarding MSH2, as well as literature-derived evidence supporting its association with microsatellite instability and hereditary non-polyposis colorectal cancer.