MSH2 and cancer: MSH2 c.2732T>A (p.L911R) was predicted by PROVEAN to be “deleterious” to protein function, implying that this is a case of a disease-associated variant (amino acid variant that deviates from the frequently occurring residue) and was assigned a driver mutation score close to zero (a driver score close to zero implies increased likelihood of the mutation being a cancer driver) for colon cancer (by CRAVAT).