MYO1E and kidney disorder: Taken together with our previous findings that Myo1e-null mice develop FSGS-like disease, and that cultured podocytes expressing Myo1e(A159P) exhibit defects in the formation of cell-cell contacts (Bi et al., 2013; Krendel et al., 2009), our data strongly indicate that the loss of function of Myo1e is the cause of kidney disease in individuals who are homozygous for the T119I or A159P mutations (Al-Hamed et al., 2013; Mele et al., 2011; Sanna-Cherchi et al., 2011).