TMEFF1 and cardiac hypertrophy: We found that the expression of tomoregulin-1 was also increased significantly in the myocardium from the cTnTR92Q transgenic mice and TAC-induced cardiac hypertrophy mice (Fig. 1), and we proposed that the coordinated myocardial expression pattern of tomoregulin-1 with TGFβs inhibited the hypertrophic and fibrogenic effects of this potent cytokine.