TMEFF1 and cardiac hypertrophy: In the present study, we found that the expression of tomoregulin-1 is increased in the myocardium of two mouse models – the cTnTR92Q cardiac hypertrophy transgenic mice and the thoracic aorta constriction (TAC)-induced cardiac hypertrophy mice – and we proposed a possible mechanism by which tomoregulin-1 regulates the development of cardiac hypertrophy in myocardium-specific tomoregulin-1-knockdown and myocardium-specific tomoregulin-1-overexpression mice.