We detected the expression of tomoregulin-1 in the cardiac hypertrophy myocardium from cTnTR92Q mice at 3 months of age and TAC-treated mice at 4 weeks after TAC operation, and its expression was approximately 2.8- and 2.1-fold of the WT mice, respectively (Fig. 1C,D, n=3 independent experiments, P<0.001). This evidence concerns the gene TMEFF1 and cardiac hypertrophy.