In camptothecin-induced apoptosis of the human breast carcinoma cell line T47D, both PHB1 and p53 undergo export from the nucleus to the cytoplasm after receiving apoptotic signals, and the nuclear exit of PHB1 and p53 correlate with the onset of apoptosis, as marked by PARP cleavage [25]. This evidence concerns the gene PHB1 and breast carcinoma.