TRIM5 and myeloid sarcoma: We speculate that virus particles stimulate the innate immune system through the receptor proteins TRIMs, STING, and BST-2. The discovery of TRIM5 triggering of innate immune signaling upon binding the capsid of a nucleic acid-devoid retrovirus-like particles (RVLPs) and a similar induction of innate immune signaling following virion restriction by the host factor tetherin, could be particularly interesting in relation to our present study and our previous observations of genetic associations between TRIM5 and BST-2 markers and the occurrence of MS [35].