Based on the fact that androgens play an important role in the development of ovarian cancer (Gibson et al. 2014), the purpose of the present study was to assess the role of androgen receptors and the androgen DHT on the canonical TGF-β1 signaling pathway through the assessment of a possible effect on molecules involved in proliferation such as the p21 protein. The gene discussed is CDKN1A; the disease is ovarian cancer.