To examine the functional significance of the chromosome alterations seen in the different groups, we examined a predetermined list of genes in pathways previously shown to be altered and functionally important in gliomas, including receptor tyrosine kinases (RTK), phosphatidyl-inositol-3-kinase, NF-κB, P53, and cell cycle regulators (Fig. 5b). The gene discussed is TP53; the disease is central nervous system cancer.