The results from ELISA assays showed that the secreted HSP47 was elevated significantly in the plasma of SSc patients compared with that of normal controls (5.4 ± 0.2 ng/mL vs. 3.3 ± 0.1 ng/mL, P = 0.0025; Fig. 1A). The gene discussed is SERPINH1; the disease is systemic sclerosis.