Although Funke et al3 found no association between 4 genetic markers of HMOX1 with susceptibility for PD, other group found a synergistic association of HMOX1 rs2077146TT genotype both with glycogen synthase kinase 3-beta (GSK3beta) gene4 and with pesticides exposure,5 increasing the risk for PD. This evidence concerns the gene GSK3B and Parkinson disease.