This is of importance when taking into account of the following facts and findings that: 1) CFH is an inhibitor of complement activation and is involved in AMD pathogenesis; 2) CFH is mainly expressed in RPE in the eye; 3) RPE is close to choroidal vessels; and 4) any damage to RPE cells may cause local complement activation which may be a trigger for local inflammation and result in CNV formation. This evidence concerns the gene CFH and age-related macular degeneration.