In addition to KRS-dependent E-cadherin expression, ERK1/2 activity and paxillin expression and activity following the formation of a complex between KRS, p67LR, and integrin α6β1 are thus important for the dissemination of single and/or small-groups of cells from colon cancer spheroids embedded in 3D collagen I gels (Figure 6F). The gene discussed is KARS1; the disease is malignant colon neoplasm.