Our data indicated that co-treatment of diosgenin with DOX for four weeks improved cardiac function during the DOX-induced cardiomyopathy, as demonstrated by improvements in body weight, heart weight, as well as in functional parameters including heart rate, blood pressure, and serum levels of LDH, CPK and CK-MB (Table 2). The gene discussed is PIK3C2A; the disease is cardiomyopathy.