PDE6B and leukemia: In addition to the rd1 mouse, there is another mouse model for recessive retinal degeneration that also carries pde6b gene mutation called rd10. The differences existing in the genetic mutations of these to mouse model are that the rd10 mouse carries a missense mutation (R560C) in exon 13 of the pde6b gene, whereas rd1 mutation is caused by an insertion of murine leukemia provirus near the first exon combined with a point mutation which introduces a stop codon in exon 7.