The Th2 cytokines IL-4 and IL-13 bind to the IL-4/IL-13R to activate STAT-6, which plays a major role in mediating a variety of phenotypic endpoints in allergic airway inflammation, including eosinophilia, mucous cell metaplasia, and airway fibrosis [12,40]. Here, IL4 is linked to Increased total eosinophil count.