Accordingly, the chemoattracting effect of CXCL12 on CXCR4+ pancreatic cancer cells might reflect a major cause for the formation of metastases directly where CXCL12 is highly expressed such as in lymph nodes, in the liver, lungs, and bone marrow [15]. The gene discussed is CXCR4; the disease is familial pancreatic carcinoma.