In contrast, a loss-of-function mutation in Fgfr3 in humans causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome (OMIM 610474) [31,32], and Fgfr3 deletion in mice leads to skeletal overgrowth due to enhanced proliferation of growth plate chondrocytes [33,34]. Here, FGFR3 is linked to Camptodactyly - tall stature - scoliosis - hearing loss.