When we compared the GRP78 protein expression in the lens of these three types of cataracts with the normal control, the GRP78 protein level in the lens of age-related cataracts, HM-related cataracts and congenital cataracts were greatly up-regulated, and this up-regulation was most significant in the lens of HM-related cataracts. Here, HSPA5 is linked to early-onset non-syndromic cataract.