CKAP5 and cancer: Moreover, the amount of TACC3–ch-TOG–clathrin at the spindle is limited by the availability of phosphorylated TACC3 (LeRoy et al., 2007; Hood et al., 2013), and since Aurora-A kinase is amplified or upregulated in a wide range of cancers (Nikonova et al., 2013), it is possible that hyperstabilization of K-fibers occurs in these cells.