IC50 values for c-Src (0.91), HER2 (0.95), FGFR-1 (0.75), c-Met (0.16) and ALK (0.15), which are often activated in NSCLC, are less than that for EGFR (1.7) (S1 Table, updated data from ref. 20), indicating that TAE226 may also inhibit these kinases in addition to EGFR in NSCLCs, especially if the tumors are “addicted” to these kinases. The gene discussed is ALK; the disease is non-small cell lung carcinoma.