SERPINB1 belongs to the serine protease inhibitor family of antiproteases, and inhibits both elastase-like and chymotrypsin-like proteases, including Cathepsin G. It has been implicated in providing defense against microorganisms at mucosal surfaces by protecting against protease-mediated inflammatory damage of the epithelium induced during bacterial infections, and promoting wound healing [50]. Here, SERPINB1 is linked to bacterial infectious disease.