The gene sets that positively correlated with the treated phenotype (i.e. they were hyper-expressed following treatment) included those found up-regulated in MM1.S cells treated with the tyrosine kinase inhibitor adaphostin [22] (Supplementary Figure 4A–4B), and in response to the Ras-inhibitor salirasib in a panel of cancer cell lines with constitutively active HRAS [23] (Supplementary Figure 4C–4D). The gene discussed is HRAS; the disease is cancer.