In order to estimate the frequency of BRAF mutations in different forms of PC dyscrasias, 167 specimens (132 MM, 24 pPCLs and 11 sPCLs) and 21 HMCLs underwent NGS of the mutational hot-spots, namely exons 11 and 15 (Cosmic Release v70, at http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/). The gene discussed is BRAF; the disease is Miyoshi myopathy.